Pharm Ingredients
Cytisine Powder
Factory Direct Price Sophora Alopecuroide Extract 98% Cytisine Powder
Cytisine, also known as Cytisinicline, Baptitoxine, Sophorine, is a quinolone alkaloid mainly found in the seeds of plants in the genus Cytisus of the legume family. It is a plant alkaloid with a high binding affinity to nicotine acetylcholine receptors. In recent years, various biological activities of cytisine have been gradually discovered, including effects such as smoking cessation, respiratory promotion, analgesia, and anti-tumor activity.
Clinically, it is mainly used to treat reflex respiratory arrest caused by surgical trauma, war wounds, asphyxiating agents, anesthetics, etc., as well as respiratory and cardiovascular failure caused by infectious diseases, shock, collapse, and neonatal asphyxia.
Kintainutri® factory specializes in supplying natural Sophora Alopecuroide extract Cytisine powder. Through high-performance liquid chromatography (HPLC) testing, its purity can reach up to 98%. We strictly adhere to GMP standards to ensure top-notch quality. As a result, our 98% alkaloid cytisine has become a popular product, sold in over 30 countries.
Cytisine Powder Extraction Source Advantages
1. Natural Source of Extraction
Sophora flavescens, a legume, is widely distributed in many parts of Northwest China (Shaanxi, Inner Mongolia, etc.). Its wild resources are abundant and can be cultivated on a large scale, making raw materials readily available. Its seeds, stems, and leaves contain high levels of cytisine, providing a sufficient and high-quality material basis for extraction.
2. Long-standing medicinal foundation
Sophora flavescens has a long history of use in traditional Chinese medicine, and its effects of clearing heat and detoxifying, killing parasites and promoting diuresis have been verified through long-term clinical practice. This provides valuable experience and preliminary safety evidence for the development of new drugs based on sophora flavescens, such as cytisine.
3. Good biocompatibility
Cytisine, derived from bitter bean, is a purely natural alkaloid, avoiding the harmful byproducts that may be generated during chemical synthesis, thus offering greater safety. This natural origin also makes it more compatible with biological organisms, making it particularly suitable for fields with extremely high safety requirements, such as medicine and animal husbandry.
4. Multiple synergistic components
In addition to cytisine, bitter bean also contains a variety of bioactive components such as matrine and oxymatrine. These components themselves have traditional effects such as anti-inflammatory and antimicrobial properties, and can interact with cytisine to produce a synergistic effect, thereby enhancing its comprehensive pharmacological potential and application value.
5. Green and sustainable production
Extracting cytisine from bitter beans is more in line with the environmental principles of green chemistry compared to chemical synthesis. Obtaining raw materials through sustainable biocultivation is more environmentally friendly and also meets the current market's urgent need for natural medicines and sustainable development models.
Cytisine Mechanism of Action
Cytisine is a plant alkaloid with a structure similar to nicotine. Its core mechanism of action lies in its role as a partial agonist of the α4β2 nicotine acetylcholine receptor. This receptor plays a central role in the reward pathway of nicotine addiction. Baptitoxine competes with nicotine for the same receptor binding site, and due to its stronger binding affinity, it can gradually replace nicotine. Simultaneously, as a low-efficacy agonist, it produces only moderate neural stimulation.
This dual effect can both reduce nicotine-induced dopamine release and weaken the reward effect of smoking, and effectively alleviate withdrawal symptoms during the smoking cessation process. In addition, it can also produce various pharmacological activities such as neuroprotection by acting on other receptor subtypes.
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Cytisine Powder HPLC Analysis Report
Cytisine Powder Benefits
1.Effectively quit smoking and drinking 
Cytisine can efficiently bind to nicotinic acetylcholine receptors, reducing nicotine dependence and cravings, and has been clinically proven to significantly improve smoking cessation success rates. It can also reduce alcohol intake and decrease alcohol dependence and relapse by regulating the brain's dopamine system.
2.Analgesic Effect
It has shown analgesic effects in animal models, with effects superior to nicotine. This is related to its selectivity for specific nicotinic receptor subtypes, and it may be developed into an analgesic drug.
3.Inhibit malignant tumors
It can induce apoptosis in various cancer cells, including liver and lung cancer, through mitochondrial pathways and endoplasmic reticulum stress, exhibiting a dose-dependent antitumor effect. Cytisine powder can also inhibit tumor growth by generating reactive oxygen species and affecting related signaling pathways, leading to cell cycle arrest.
It can induce apoptosis in various cancer cells, including liver and lung cancer, through mitochondrial pathways and endoplasmic reticulum stress, exhibiting a dose-dependent antitumor effect. Cytisine powder can also inhibit tumor growth by generating reactive oxygen species and affecting related signaling pathways, leading to cell cycle arrest.
4.Regulate blood sugar levels
As an nicotinic acetylcholine receptor agonist, baptitoxine can regulate dopamine levels in the brain, reduce sucrose intake, and help control blood sugar. For diabetic patients, it can improve the sluggish adrenaline response caused by recurrent hypoglycemia and prevent hypoglycemia-related autonomic dysfunction.
As an nicotinic acetylcholine receptor agonist, baptitoxine can regulate dopamine levels in the brain, reduce sucrose intake, and help control blood sugar. For diabetic patients, it can improve the sluggish adrenaline response caused by recurrent hypoglycemia and prevent hypoglycemia-related autonomic dysfunction.
5.Protect nerve health
It can exert a wide range of neuroprotective effects by activating specific nicotinic receptors. It can reduce epileptic seizures, improve cognition, combat Parkinson's disease by promoting dopamine release and iron integration, and protect cortical neurons from excitotoxicity and ischemia-reperfusion injury.
6.Regulate cardiovascular function
Cyperine can effectively enhance the contractile force of papillary muscles in guinea pig hearts, improve their automaticity, and accelerate heart rate. It can also inhibit sodium channel currents in rat ventricular myocytes, altering their kinetic properties, thereby exerting an antiarrhythmic effect.
7.Prevention and treatment of osteoporosis
It can significantly inhibit the generation and differentiation of osteoclasts, reduce bone loss in ovariectomized mice through multiple signaling pathways, and prevent osteoporosis.
8.Other potential benefits
Sophorine is used as an emetic, laxative, respiratory stimulant, and diuretic in europe; it can also effectively enhance motor skills, reduce depressive-like behaviors, and shows potential in antimicrobial, anti-ulcer, and anti-inflammatory effects. Furthermore, it can help control weight and enhance cognitive and memory functions by modulating specific neurons, demonstrating broad clinical application prospects.
What is Cytisine Used For？
1. Pharmaceutical and healthcare industry
· Cytisine is primarily used in the development of smoking cessation aids, leveraging its partial agonist properties to help reduce nicotine dependence. It is used in the development of oral tablets, lozenges, and other formulations, and is an important component of smoking cessation programs in many European and Eastern countries.
· Furthermore, its potential pharmacological activities, such as neuroprotection and antidepressant effects, also demonstrate its promising prospects in new drug development, particularly in the treatment of neurological disorders.
2. Scientific research and pharmacological research
Sophora Alopecuroide Extract Powder is widely used in neuroscience research, particularly to explore the mechanism of action of nicotinic acetylcholine receptors in addiction. It is also used to develop novel smoking cessation drugs or to study the pharmacological properties of partial agonists.
3. Agriculture and Animal Husbandry
· It is primarily used in the development of novel insecticides, exhibiting highly effective killing properties against lepidopteran pests and less likely to induce resistance in them.
· It can also be used as a natural feed additive, effectively inhibiting the reproduction of parasites in livestock and poultry, ensuring their healthy growth. Compared to chemical insecticides, it is safer, leaving no residue in livestock and poultry products, thus ensuring food safety.
Cytisine Powder cytisinicline side Effects
1. Common adverse reactions
Sophorine may cause gastrointestinal discomfort, such as indigestion and nausea. Other common reactions include headache, dry mouth, increased appetite, irritability, and nightmares.
2. Contraindications and Population
Pregnant and breastfeeding women should avoid use due to a lack of relevant safety information. Additionally, it is contraindicated for patients with severe atherosclerosis or uncontrolled hypertension.
3. Cytisine Drug Interactions
Currently, data on the interactions between cytisine and other drugs are very limited. It should be avoided when using it concurrently with other smoking cessation medications to prevent unknown risks.
4. Toxic Reactions
Cytisine toxicity is dose-dependent and can be life-threatening in severe cases. There have been reports of respiratory failure and death due to ingestion of its plant material.
Where to Buy Cytisine Powder?
If you have a need for cytisine powder, Xi'an Kintai is your preferred factory. Our sophorine powder is extracted from natural Sophora Alopecuroide, boasting 98% high purity, low impurity content, stable quality, and compliance with application standards across multiple industries.
As a leading supplier of herbal extracts in China, we have obtained ISO, cGMP, and HACCP certifications to ensure the highest quality and safety of our products. Our professional team strictly adheres to cGMP standards throughout the entire production process, committed to providing best cytisine.
Should you be interested in our Sophora Alopecuroide extract cytisine products, contact us via email at: natural@kintaibio.com or visit our official website for more product information!
